I've got no sound, Visual Studio 2003 is a bit unsure of its new environment, it took me an hour to fix up my source control installation due to Vista clobbering file permissions, UAC is crap (I have turned it off and turned off the warning telling me to turn it back on) and SonicWall VPN Client doesn't work but... Vista is actually pretty good. Search works quickly for the first time ever in Windows (and searches emails as well!), the new UI is actually quite beautiful (something that could never be said about the XP Fisher-Price look), IIS 7 is a damn fine upgrade (although it took a while to get my ASP.NET 1.1 apps up and running) and performance seems to be pretty much the same as XP, which is quite remarkable given all the visual additions and extra services that have been added.
No doubt the Mac did it better two years ago but the Mac doesn't have any apps I need. My Mac OSX box sits unloved in the corner with nothing to do...